2. Signaling Pathways
  3. Epigenetics
  4. Histone Demethylase
  5. KDM3 Isoform
  6. KDM3 Degrader

KDM3 Degrader

KDM3 Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-183618
    DW-229
    		Degrader
    DW-229 is a PROTAC degrader derived from Deferiprone (HY-B0568), targeting Fe(II)/α‑ketoglutarate‑dependent histone lysine demethylases (KDMs). DW-229 degrades KDM2A, KDM3A, KDM5B, KDM4A‑C, KDM5C, KDM6B in breast cancer cells. DW-229 shows IC50 < 0.5 μM against MCF‑7 cells and IC50 of 8.87 μM against MDA‑MB‑231 cells, with high cancer cell selectivity. DW-229 can be used for the research of breast cancer, liver cancer, prostate cancer, lung cancer.